The Palpable Prostate

Prostate cancer topics, links and more. Now at 100+ posts!

News: Health Day, Medical News Today, ScienceDaily, Urol Times, Urotoday, Zero Cancer Papers: Pubmed (all), Pubmed (Free only), Amedeo
Journals: Eur Urol, J Urol, JCO, The Prostate Others Pubmed Central Journals (Free): Adv Urol, BMC Urol, J Endourol, Kor J Urol, Rev Urol, Ther Adv Urol, Urol Ann
Reviews: Cochrane Summaries, PC Infolink Newsletters: PCRI, US Too General Medical Reviews: f1000, Health News Review
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Monday, June 1, 2015

Less lethal prostate cancer among those diagnosed with asthma

In a review of the Health Professionals Follow Up study (47,000 men) researchers found the proportion of subjects with lethal prostate cancer was 29% less among those who had been diagnosed with asthma vs. those who had not.   For those had been disagosed with hayfever the risk was 10% higher.  

The finding for asthma is odd because both prostate cancer and asthma are thought to be related to inflammation so that if there were a correlation the risk of lethal prostate cancer would be expected to be higher, not lower.
See [PMID: http://www.ncbi.nlm.nih.gov/pubmed/25648070] and [Science Daily]

Thursday, April 30, 2015

4-MU

A study of prostate cancer in a mouse model published this month [PMID: 25868577] concludes that "4-MU is an effective nontoxic, oral chemopreventive, and therapeutic agent that targets PCa development, growth, and metastasis by abrogating HA signaling." 4-MU (short for 4-Methylumbelliferone). It is also known as Hymecromone. It works by inhibiting hyaluronic acid.

Regarding the animal studies the researchers said:
"We found that when treatment started early, at eight or 12 weeks it completely inhibited prostate cancer development and growth ...  At 22 weeks, we found small cancers that had stopped growing and even regressed in some cases. Also to our amazement, while 60 percent of the animals in the control group experienced metastasis to distant organs, none in the treatment group developed metastasis. 4-MU did all of this without causing any toxicity to the host." Quoted in this News article

Although success in mice models is far from success in humans if 4-MU were effective for prostate cancer in humans as well, it would have the advantages that:
  1. it is already an approved for use in Europe and Asia (in Italy it goes by the name Cantabilin® for biliary applications and is called Cantabiline® in France and Belgium and in other countries by other names).
  2. Numerous human trials of 4-MU have been carried out.  See Table; however, these trials were for use in non-cancer applications and safety in cancer applications does not necessarily follow.  For example, if higher doses were required for cancer application at those higher doses there could be additional safety concerns; nevertheless, this is better from the viewpoint of unknown risks than a completely new drug.
A March, 2015 review of 4-MU appears here: [PMID: 25852691]

Tuesday, March 31, 2015

Blog updates for March 2015

March 15, In USPSTF Draft Report we added: Partly due to the controversy that this decision has generated, a new bipartisan bill HR1151 designed to reform the USPSTF process is under consideration.  The bill is supported by the American Urological Association (AUA).  A summary of some of the key points is available in this [June 3, 2013 Urology Times article] and this [March 11, 2015 Medscape article].

March 15. In Fasting we added: A recent experiment on fruit flies supports this idea [of only eating during certain hours of a day] finding that fruit flies who were restricted to eat within a 12 hour window each day had superior cardiac health than fruit flies allowed to eat any time they wished. See [PMID: 25766238] and [San Diego University news release].

March 25. In USPSTF Draft Report we added: A 36 minute presentation by Peter C. Albertsen largely in support of the USPSTF recommendations is found at [January 14, 2015 UBC Urology Rounds]

Saturday, February 28, 2015

Extrapolating the increase in prostate cancer diagnoses

"prostate cancer cases increased by 54% between 1975 and 2010, but mortality declined by 30% over the same period." [link]

Focusing on the increasing number of men diagnosed, "Our earliest data point comes from 1973. Back then, 1 man in 16 could expect to be diagnosed with the disease. Between 1973 and 2013, 38 available data points document the increase in the reported incidence of prostate cancer over 40 years." [link] The current proportion is 1 in 6 or 1 in 5. This proportion seems to be increasing linearly with time and based on linear extrapolation half of all men will be diagnosed with prostate cancer by 2124 (110 years from now). See this [figure] illustrating the extrapolated regression cursve.

Sunday, February 1, 2015

Fasting

[Updated March 15, 2015] The AICR/WCRF report on nutrition and cancer does point out that "Restriction of energy intake from food is the most effective single intervention for preventing cancer in experimental animals."
[link]

Unfortunately, the evidence for the anti-cancer effet of fasting is mostly based on animal studies or in human studies with significant limitations. Furthermore, not all the evidence is positive and there have been some negative results such as this study which found no benefit to fasting twice a week in mice injected with prostate cancer cells:
[PMID: 20733612]

Dr. Yu offers the opinion that fasting may be more useful in conjunction with other methods than by itself. [Youtube video]

A survey paper on fasting and cancer in animal studies is available here: [PMC4263749].

Some ways fasting might be carried out are:

- continuous calorie restriction.  Reduce the number of calories eaten each day.

- daily intermittent fasting.  Only eat within a prescribed time window every
  day.  This diet is described in the Fast 5 diet on the [Fast 5 web site] and
  in the free downloadable ebook on that site. It discusses fasting for 19
  continuous hours and eating only within the remaining 5 hours each day.
  [Fast 5 web site]
  [Fast 5 ebook]
  [Fast 5 discussion]
A recent experiment on fruit flies supports this idea finding that fruit flies who were restricted to eat within a 12 hour window each day had superior cardiac health than fruit flies allowed to eat any time they wished. See [PMID: 25766238] and [San Diego University news release].
- Alternate Day Fasting.  Every other day reduce calories to 25% of normal.

- weekly intermittent fasting.  On the 5:2 diet one eats normally 5
  days a week and reduces calories to 25% of normal on 2 non-consecutive
  days a week.  The diet is described in the book Michael Mosley, The Fast
  Diet: Lose Weight, Stay Healthy, and Live Longer.

- monthly intermittent fasting.  Dr. Vatter Longo has been experimenting
  on humans with a diet in which one eats normally for 25 days and then
  reduce calories to 25% of normal for 5 days.  (It has also been
  hypothesized that eating normally for 55 day and reducing calories
  to 25% for 5 days might be give the same benefit.)
  [BBC News]
  [Valter Longo - Wikipedia]

Note that many of these diets have been considered only from the viewpoint of weight loss and not from the viewpont of any potential anti-cancer effect.

The area where some evidence is available is that human studies have found that fasting before and after chemotherapy seems to heighten the anti-cancer effect and reduces adverse side effets.
[PDF]

Many of the mechanisms underlying fasting are known. The following
survey paper is aimed at fasting and chemotherapy but it also describes,
in general, the various biological mechanisms underlying fasting:
[PDF]

Thursday, January 1, 2015

Blog Updates for December 2014

Jan 1, 2015. In WCRF/AICR Diet and Cancer Report we added: In November of 2014 an update to the original report was published with the following main conclusions. From their web site:
  • "There is strong evidence that being overweight or obese increases the risk of advanced prostate cancer (being overweight or obese is assessed by body mass index (BMI), waist circumference and waist-hip ratio)."
  • "There is strong evidence that developmental factors in the womb, childhood, and adolescence that influence growth are linked to an increased risk of prostate cancer (the taller a man is, the greater his risk of prostate cancer)."
  • "There is strong evidence that consuming beta-carotene (either through food or supplements) is unlikely to have a substantial effect on the risk of prostate cancer."

Monday, December 1, 2014

Blog Updates for November 2014

November 3, 2014.  Added new Twitter category to the Links in the right margin.  New entries: Twitter: [D Martin] [Prostate Urology]