March 22, 2012. In Biochemical PSA Recurrence we added: Regarding aspirin, which is listed in the table just cited, further evidence in support of aspirin's anticancer effect was published in March 2012 in several papers in the Lancet. See this [Medscape summary] which also provides links to the papers. The effect in reducing the risk of metastasis was quite large for adenocarcinomas (95% of all prostate cancers are adenocarcinomas). GI bleeding is one adverse side effect although it was found that after a period of time that side effect was reduced.
March 22, 2012. In Biochemical PSA Recurrence we added: A typical protocol might be to start following the patient more closely if PSA reaches 0.05 to build up a history of PSA values and if there is no evidence of systemic disease to proceed to radiation by the time the PSA reaches 0.3 or 0.4 . This would put the patient in the most favourable risk group (represented by the blue line in panel B of Stephenson et al 2007 [Figure 1] of [PMID: 17513807] [full text]).
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